ISM7594
ISM7594 is an orally active FGFR2/3 inhibitor. ISM7594 shows broad-spectrum antiproliferative potency in FGFR2- or FGFR3-altered cancer cell panels, including FGFR2/3 amplification, fusion, and mutation (BaF3-TEL-FGFR2-V564F (IC50 = 0.067 nM), BaF3-TEL-FGFR2-V564I (IC50 = 2 nM) ) types. ISM7594 inhibits tumor growth in a dose-dependent manner. ISM7594 can be used for the study of advanced solid tumors with FGFR2/3 aberrations[1].
Product Specifications
CAS Number
[3025799-76-9]
UNSPSC
12352005
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=C(C(NC1=CC=C(C=C1)C2=C(C3=CC=C(C(F)=C3)OC4=NC=CC(C)=N4)C(C(N)=O)=C5C=C(C=NN52)C)=O)F
Molecular Formula
C29H22F2N6O3
Molecular Weight
540.52
References & Citations
[1]Wang Y, et al. Rational Design and Identification of ISM7594 as a Tissue-Agnostic FGFR2/3 Inhibitor. J Med Chem. 2025 Jul 10;68 (13) :13887-13906.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR1; FGFR2; FGFR3; FGFR4
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