7-keto-25-Hydroxycholesterol

7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo[1].

Product Specifications

CAS Number

[64907-23-9]

Product Name Alternative

7-keto-25-OHC

UNSPSC

12352211

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-keto-25-hydroxycholesterol.html

Smiles

CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])C(C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O

Molecular Formula

C27H44O3

Molecular Weight

416.64

References & Citations

[1]Benjamin R Myers, et al. Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell. 2013 Aug 26;26 (4) :346-57.