AZ12943203

AZ12943203 (Compound 13e) is a GSK-3 PET radioligand with a Kd of 2.94 nM. AZ12943203 has a significant inhibitory potency toward GSK-3β (IC50 : 4.44 nM), and can specifically bind to GSK-3-rich regions of the rodent brain. AZ12943203 can be used for neurodegenerative diseases imaging, particularly Alzheimer’s disease[1].

Product Specifications

UNSPSC

12352005

Target

Biochemical Assay Reagents; GSK-3

Related Pathways

Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC(N1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CN=C(C)N4C5CCOCC5)=N3)C=C2)CC1)=O

Molecular Formula

C26H32FN7O2

Molecular Weight

493.58

References & Citations

[1]Li Y, et al. Radiosynthesis and Evaluation of 11C-Labeled Imidazolyl Pyrimidine Derivatives for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3[J]. ACS Pharmacology & Translational Science, 2025.