AZ12943203
AZ12943203 (Compound 13e) is a GSK-3 PET radioligand with a Kd of 2.94 nM. AZ12943203 has a significant inhibitory potency toward GSK-3β (IC50 : 4.44 nM), and can specifically bind to GSK-3-rich regions of the rodent brain. AZ12943203 can be used for neurodegenerative diseases imaging, particularly Alzheimer’s disease[1].
Product Specifications
UNSPSC
12352005
Target
Biochemical Assay Reagents; GSK-3
Related Pathways
Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC(N1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CN=C(C)N4C5CCOCC5)=N3)C=C2)CC1)=O
Molecular Formula
C26H32FN7O2
Molecular Weight
493.58
References & Citations
[1]Li Y, et al. Radiosynthesis and Evaluation of 11C-Labeled Imidazolyl Pyrimidine Derivatives for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3[J]. ACS Pharmacology & Translational Science, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Monoclonal MLH1 Antibody (MLH1/8855R) [Alexa Fluor 647]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
NBP3-24227AF647 0.1 mL
Rabbit Monoclonal MLH1 Antibody (MLH1/8855R) [Alexa Fluor 647]
Sign In for Pricing
View Details 
LV727325 1.0 µg DNA
HBXIPP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details MBS9326839-01 48 Well
Human Ubiquitin carboxyl-terminal hydrolase 11, USP11 ELISA Kit
Sign In for Pricing
View Details MBS9326839-02 96 Well
Human Ubiquitin carboxyl-terminal hydrolase 11, USP11 ELISA Kit
Sign In for Pricing
View Details MBS9326839-03 5x 96 Well
Human Ubiquitin carboxyl-terminal hydrolase 11, USP11 ELISA Kit
Sign In for Pricing
View Details