PROTAC BRD4 Degrader-34
PROTAC BRD4 Degrader-34 (Compound MZ2) is a selective BRD4 PROTAC degrader (pDC50 = 8.4) . PROTAC BRD4 Degrader-34 can induce BD2 degradation mediated by VHL. PROTAC BRD4 Degrader-34 can be used for research on cancer. (Pink: BRD4-BD2 Ligand (HY-78695) ; Blue: VHL Ligand (HY-125845) ; Black: Linker (HY-130524) ) [1].
Product Specifications
CAS Number
[1797406-70-2]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCNC(C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C(C(C)=C(C)S6)=C6N7C4=NN=C7C)=O)=O)=O)=O)C=C2)SC=N1
Molecular Formula
C51H64ClN9O9S2
Molecular Weight
1046.69
References & Citations
[1]Kudo G, et al. Construction of PROTAC-Mediated Ternary Complex Structure Distribution Profiles Using Extensive Conformational Search. J Chem Inf Model. 2025 Jul 14;65 (13) :6939-6948.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; von Hippel-Lindau (VHL)
Curated Selection
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