Factor B-IN-5

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy[1].

Product Specifications

CAS Number

[1644670-23-4]

UNSPSC

12352005

Target

Complement System

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

CC1=CC(OC)=C(CN2CC[C@@H](C)C[C@H]2C3=CC=C(C(O)=O)C=C3)C4=C1NC=C4

Molecular Formula

C24H28N2O3

Molecular Weight

392.49

References & Citations

[1]Li ZH, et al. A piperidinyl indole derivative, potential complement factor B inhibitor, plays a renoprotective role in diabetic nephropathy. Diabet Med. 2025 Aug;42 (8) :e70092.