Factor B-IN-5
Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy[1].
Product Specifications
CAS Number
[1644670-23-4]
UNSPSC
12352005
Target
Complement System
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
CC1=CC(OC)=C(CN2CC[C@@H](C)C[C@H]2C3=CC=C(C(O)=O)C=C3)C4=C1NC=C4
Molecular Formula
C24H28N2O3
Molecular Weight
392.49
References & Citations
[1]Li ZH, et al. A piperidinyl indole derivative, potential complement factor B inhibitor, plays a renoprotective role in diabetic nephropathy. Diabet Med. 2025 Aug;42 (8) :e70092.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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