FLT3-IN-33
FLT3-IN-33 (Compound 7r) is a FLT3 inhibitor with an IC50 of 7.82 nM. FLT3-IN-33 has superior anticancer activities against acute myeloid leukemia (AML) cells, such as MV4-11 and MOLM-13 cells. FLT3-IN-33 significantly induces cell apoptosis and inhibits phosphorylation of FLT3 pathways. FLT3-IN-33 can be used for AML and other cancers research[1].
Product Specifications
CAS Number
[3035801-67-0]
UNSPSC
12352005
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN1CCN(C2=CC=C3C(N=C(C4=CN=C(NCCC)N=C4N[C@@H]5CC[C@@H](O)CC5)N3)=C2)CC1
Molecular Formula
C25H36N8O
Molecular Weight
464.61
References & Citations
[1]Du K, et al. Design, Synthesis, and Biological Evaluation of Potent FLT3 Inhibitor for Acute Myeloid Leukemia (AML) Treatment. Drug Dev Res. 2025 Aug;86 (5) :e70119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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