SJL2-1
SJL2-1 is a PRMT5 inhibitor, with an IC50 of 1.56 μM. SJL2-1 suppresses proliferation, migration, and invasion in prostate cancer cells. SJL2-1 promotes apoptosis and blocks the cell cycle at the G0/G1 phase. SJL2-1 can target the binding of PRMT5 in cells and inhibit the methylation and expression of the androgen receptor. SJL2-1 can be used for the study of early androgen-sensitive prostate cancer and advanced castration-resistant prostate cancer (CRPC) [1].
Product Specifications
UNSPSC
12352005
Target
11β-HSD; Androgen Receptor; Histone Methyltransferase
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=CN(CC(CN2C(C)C(C=CC=C3)=C3CC2)O)C4=CC=CC=C41
Molecular Formula
C22H26N2O
Molecular Weight
334.45
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-174908/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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