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ITK-IN-6

ITK-IN-6 is a highly potent and selective ITK inhibitor (Kd = 387 nM) . ITK-IN-6 directly binds to the ITK kinase domain. ITK-IN-6 blocks the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus and IgE production. ITK-IN-6 significantly inhibits airway inflammation and is used in asthma research[1].

Product Specifications

CAS Number

2616666-32-9

UNSPSC

12352005

Target

Itk

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology

Smiles

OC1=C(NS(=O)(C)=O)C=C(NC(C2=CC=C(C3=C(Cl)C(Cl)=CC=C3)C=C2)=O)C=C1

Molecular Formula

C20H16Cl2N2O4S

Molecular Weight

451.32

References & Citations

[1]Zhaoxi Guo, et al. A Novel Small Molecule ITK Inhibitor Suppresses Th2/Th17 Differentiation and Attenuates Airway Inflammation in a Mouse Model of HDM-Induced Asthma. Immunology. 2025 Jun 12.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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