ITK-IN-6
ITK-IN-6 is a highly potent and selective ITK inhibitor (Kd = 387 nM) . ITK-IN-6 directly binds to the ITK kinase domain. ITK-IN-6 blocks the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus and IgE production. ITK-IN-6 significantly inhibits airway inflammation and is used in asthma research[1].
Product Specifications
CAS Number
2616666-32-9
UNSPSC
12352005
Target
Itk
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
OC1=C(NS(=O)(C)=O)C=C(NC(C2=CC=C(C3=C(Cl)C(Cl)=CC=C3)C=C2)=O)C=C1
Molecular Formula
C20H16Cl2N2O4S
Molecular Weight
451.32
References & Citations
[1]Zhaoxi Guo, et al. A Novel Small Molecule ITK Inhibitor Suppresses Th2/Th17 Differentiation and Attenuates Airway Inflammation in a Mouse Model of HDM-Induced Asthma. Immunology. 2025 Jun 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
