THR-β agonist 9

THR-β agonist 9 is a potent, selective, and His435 mutation-sensitive THR-β (EC50: 3.2 nM) agonist. THR-β agonist 9 has moderate selectivity (approximately 10-fold) and good activation capacity (EC50: 134.2 nM to 515.5 nM) for multiple His435 mutants (H435A, H435Y, and H435R) . THR-β agonist 9 has the potential to be used in the study of dyslipidemia, metabolic dysfunction-associated steatohepatitis (MASH), or resistance to thyroid hormone (RTH) [1].

Product Specifications

CAS Number

[2920045-74-3]

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase; AMPK; Mitochondrial Metabolism; Thyroid Hormone Receptor

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

OC1=C(C(NCC(O)=O)=O)N=C(OC)C2=CC(OC3=CC=C4C(C=CC=C4)=C3)=CC=C21

Molecular Formula

C23H18N2O6

Molecular Weight

418.40

References & Citations

[1]Li Q, et al. Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2025 Jul 10;68 (13) :13471-13490.