Dioxopiperidin-phthalimidine-PEG3-NBoc

Dioxopiperidin-phthalimidine-PEG3-NBoc is a conjugate of the CRBN ligand (HY-138793) and the linker (E3 Ligase Ligand-Linker Conjugate) . Dioxopiperidin-phthalimidine-PEG3-NBoc can be used for synthesizing Bcl-xL PROTAC degrader PZ671 (HY-174876) [1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N(C(CC2)C(NC2=O)=O)CC3=C1C=CC(CCCOCCOCCOCCN(C)C(OC(C)(C)C)=O)=C3

Molecular Formula

C28H41N3O8

Molecular Weight

547.64

References & Citations

[1]Zhang P, et al. Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader. RSC Med Chem. 2025 May 23.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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