BCL-xL ligand 2
BCL-xL ligand 2 is a ligand for BCL-xL. BCL-xL ligand 2 can be conjugated with E3 ligase Ligand and linker to synthesize Bcl-xL PROTAC degrader PZ671 (HY-174876).
Product Specifications
UNSPSC
12352005
Target
Bcl-2 Family; Ligands for Target Protein for PROTAC
Related Pathways
Apoptosis; PROTAC
Field of Research
Cancer
Smiles
O=C(NS(=O)(C1=CC=C(N[C@@H](CSC2=CC=CC=C2)CC=O)C(S(=O)(C(F)(F)F)=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CCC(C)(C)C5)CC4)C=C3
Molecular Formula
C43H46ClF3N4O6S3
Molecular Weight
903.49
References & Citations
[1]Zhang P, et al. Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader. RSC Med Chem. 2025 May 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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