PROTAC HDAC6 degrader 6
PROTAC HDAC6 degrader 6 (Compound 12) is a selective HDAC6-targeting photochemically targeting chimeras (PHOTACs) (subset of PROTAC) degrader with a ∼50% Dmax only upon activation to its cis-state with 390 nm light irradiation[1]. Pink: HDAC6 ligand; Blue: CRBN ligase ligand ; Black: linker
Product Specifications
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C1CCC(N2CC3=C(C=CC=C3/N=N\C4=CC(OC)=C(OCC(NCCCC(NC5=CC=C(C(NCCCCCCC(NO)=O)=O)C=C5)=O)=O)C(OC)=C4)C2=O)C(N1)=O
Molecular Formula
C41H48N8O11
Molecular Weight
828.87
References & Citations
[1]Wurnig SL, et al. Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6. RSC Med Chem. 2025 Mar 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6
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