PZ671
PZ671 is a potent Bcl-xL PROTAC degrader with an IC50 of 1.3 nM (MOLT-4 cells) and a DC50 of 0.9 nM (Bcl-xL). PZ671 induces apoptosis in MOLT-4 cells. PZ671 effectively inhibits tumor growth and rapidly reverses transient platelet counts reduction in MOLT-4 xenograft mice. PZ671 can be used for the research of cancer, such as small cell lung cancer (SCLC). (Structure Note: Pink: Bcl-xL ligand ; Blue: CRBN Ligand (HY-138793) ; Black: linker; E3-linker (HY-174879) )
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; PROTACs
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
Molecular Formula
C66H79ClF3N7O11S3
Molecular Weight
1335.02
References & Citations
[1]Zhang P, et al. Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader. RSC Med Chem. 2025 May 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-xL; Cereblon
Frequently Asked Questions
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