(S, R, S) -AHPC-CO-C2-phenylboronic acid

(S, R, S) -AHPC-CO-C2-phenylboronic acid is an E3 ligase ligand-linker conjugate that incorporates the VH032-based VHL ligand (HY-125845) and linker. (S, R, S) -AHPC-CO-C2-phenylboronic acid can be used for synthesis of PROTAC AF151 (HY-174873) [1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Others

Smiles

CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(CCC4=CC=C(B(O)O)C=C4)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

Molecular Formula

C31H39BN4O6S

Molecular Weight

606.54

References & Citations

[1]Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19.