(S, R, S) -AHPC-CO-C2-phenylboronic acid
(S, R, S) -AHPC-CO-C2-phenylboronic acid is an E3 ligase ligand-linker conjugate that incorporates the VH032-based VHL ligand (HY-125845) and linker. (S, R, S) -AHPC-CO-C2-phenylboronic acid can be used for synthesis of PROTAC AF151 (HY-174873) [1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Others
Smiles
CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(CCC4=CC=C(B(O)O)C=C4)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1
Molecular Formula
C31H39BN4O6S
Molecular Weight
606.54
References & Citations
[1]Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
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