AF151
AF151 is a METTL3 PROTAC degrader with the DC50 of 0.43 μM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML). (Pink: METTL3 Ligand ; Blue: VHL Ligand (HY-125845) ; Black: Linker; VHL Ligand+Linker (HY-174875) ).
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; METTL3; PROTACs
Related Pathways
Apoptosis; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(CCC4=CC=C(C5=CC=C(COC6=CN=CC(C(NCC7=CC(NC(CN8CCC(C)(C)CC8)=C9)=C9C=C7)=O)=C6)C=C5)C=C4)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1
Molecular Formula
C61H70N8O6S
Molecular Weight
1043.32
References & Citations
[1]Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Mcl-1; von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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