AF151

AF151 is a METTL3 PROTAC degrader with the DC50 of 0.43 μM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML) . (Pink: METTL3 Ligand (HY-174874) ; Blue: VHL Ligand (HY-125845) ; Black: Linker; VHL Ligand+Linker (HY-174875) ) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; METTL3; PROTACs

Related Pathways

Apoptosis; Epigenetics; PROTAC

Field of Research

Cancer

Smiles

CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(CCC4=CC=C(C5=CC=C(COC6=CN=CC(C(NCC7=CC(NC(CN8CCC(C)(C)CC8)=C9)=C9C=C7)=O)=C6)C=C5)C=C4)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

Molecular Formula

C61H70N8O6S

Molecular Weight

1043.32

References & Citations

[1]Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19.