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BT-O2C

BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C can be used for research on cancer. (Pink: p300 Ligand (HY-174868) ; Blue: CRBN Ligand (HY-W023573) ; Black: Linker; CRBN Ligand+Linker (HY-174869) ) [1].

Product Specifications

CAS Number

[3055107-34-8]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Histone Acetyltransferase; PROTACs

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N(CC1=CC=C(F)C=C1)[C@@H](C)C(F)(F)F)CN(C(N[C@]23C[C@@H](F)C4=C3C=CC(C5=CN(CC(NCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)N=C5)=C4)=O)C2=O

Molecular Formula

C48H48F5N9O8

Molecular Weight

973.94

References & Citations

[1]Marsh GP, et al. Development of p300-targeting degraders with enhanced selectivity and onset of degradation. RSC Med Chem. 2025 Mar 3;16 (5) :2049-2060.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CBP/p300; Cereblon

Available Sizes

Curated Selection

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