BT-O2C
BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5). BT-O2C can be used for research on cancer. (Pink: p300 Ligand ; Blue: CRBN Ligand (HY-W023573) ; Black: Linker; CRBN Ligand+Linker (HY-174869) ).
Product Specifications
CAS Number
3055107-34-8
UNSPSC
12352005
Target
Epigenetic Reader Domain; Histone Acetyltransferase; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N(CC1=CC=C(F)C=C1)[C@@H](C)C(F)(F)F)CN(C(N[C@]23C[C@@H](F)C4=C3C=CC(C5=CN(CC(NCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)N=C5)=C4)=O)C2=O
Molecular Formula
C48H48F5N9O8
Molecular Weight
973.94
References & Citations
[1]Marsh GP, et al. Development of p300-targeting degraders with enhanced selectivity and onset of degradation. RSC Med Chem. 2025 Mar 3;16 (5) :2049-2060.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; Cereblon
Available Sizes
Frequently Asked Questions
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