MMH-165-26

MMH-165-26 is a ligand for RelA/p65. MMH-165-26 reduces the expression of RelA/p65 and has significant cytotoxicity in MEC-1 (LC50 = 0.37 μM) cells. MMH-165-26 can be used for synthesizing PROTACs such as JP-163-16 (HY-174864) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Ligands for Target Protein for PROTAC; NF-κB

Related Pathways

Apoptosis; NF-κB; PROTAC

Field of Research

Cancer

Smiles

NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1

Molecular Formula

C23H26N4O4

Molecular Weight

422.48

References & Citations

[1]Jin P, et al. Design, synthesis and evaluation of pyrrolobenzodiazepine (PBD) -based PROTAC conjugates for the selective degradation of the NF-κB RelA/p65 subunit. RSC Med Chem. 2025 May 8.