PI3K/mTOR-IN-17

PI3K/mTOR-IN-17 is a dual PI3K and mTOR inhibitor with IC50 values of 1.21 μM (PI3K), and 0.21 μM (mTOR) . PI3K/mTOR-IN-17 induces cells caspase-mediated apoptosis by arresting their growth in the G1-phase. PI3K/mTOR-IN-17 upregulates the levels of caspases-3, 7, 8, and 9, p53 expression and Bax/Bcl-2 ratio. PI3K/mTOR-IN-17 suppresses the PI3K/mTOR signaling pathway. PI3K/mTOR-IN-17 can be used for research of cancer, such as non-small cell lung cancer (NSCLC) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53; mTOR; PI3K

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(N1C2=CC=C(NC(C(C3=CC=CC=C3)N(C4=CC=C(C)C=C4)C(CNC(OC(C)(C)C)=O)=O)=O)C=C2)C5=CC=CC=C5C1=O

Molecular Formula

C36H34N4O6

Molecular Weight

618.68

References & Citations

[1]Mohammed SA, et al. Dual targeted Ugi-bisamides induce caspase-mediated apoptosis and inhibit PI3K/mTOR signaling in NSCLC. New J. Chem., 2025,49, 10102.