PySAHA
PySAHA is a multifunctional HDAC inhibitor. PySAHA can degrade intracellular HDAC via a hydrophobic tagging mechanism. PySAHA also possesses photodynamic therapeutic activity and can generate reactive oxygen species under light irradiation. PySAHA can inhibit the proliferation, migration and induce cell apoptosis of breast cancer cells. PySAHA has antitumor activity and can be used in breast cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; HDAC; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C(NO)CCCCCCC(NC1=CC=C(/N=C/C2=C(C3=C45)C=CC5=CC=CC4=CC=C3C=C2)C=C1)=O
Molecular Formula
C31H29N3O3
Molecular Weight
491.58
References & Citations
[1]Li Q, et al. A pyrene-based HDAC inhibitor for dual-action therapy of breast cancer. Chem Commun (Camb) . 2025 Jun 26;61 (53) :9693-9696.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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