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TRIM25 ligand-1

TRIM25 ligand-1 (Compound 10) is a covalent ligand. TRIM25 ligand-1 can covalently bind to Cys498 in the PRYSPRY domain of TRIM25 and enhance its auto-ubiquitination activity. TRIM25 ligand-1 is selective for TRIM25 in vitro and in live cells[1].

Product Specifications

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

CC1=CC(C(N2CCN(C(CCl)=O)CCC2)=O)=CC=C1C3=CC=CC=C3

Molecular Formula

C21H23ClN2O2

Molecular Weight

370.87

References & Citations

[1]McPhie KA, et al. Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination. Chem Sci. 2025 May 12;16 (23) :10432-10443.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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