KRAS G12C-IN-70
KRAS G12C-IN-70 is a selective KRAS G12C mutant inhibitor. KRAS G12C-IN-70 blocks KRAS G12C-mediated downstream signaling pathways (e.g., RAF-MEK-ERK) and inhibits tumor cell proliferation. KRAS G12C-IN-70 is promising for research of KRAS G12C mutation-related tumors (such as non-small cell lung cancer, colorectal cancer) [1].
Product Specifications
CAS Number
[2923865-76-1]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
C=CC(N1CCN2C(C3=C(C4=C(C5=C6C(SC(N)=C6C#N)=C(F)C=C5)C(F)=C3)N(N=C4Cl)CC[C@@H]2C1)=O)=O
Molecular Formula
C26H19ClF2N6O2S
Molecular Weight
552.98
References & Citations
[1]Li X, et al. Nitrogen-containing tetracyclic compound, preparation method therefor, and medical use thereof. WO2023066371A1. 2023-04-27.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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