TRPM8 antagonist 4 prodrug
TRPM8 antagonist 4 prodrug (Compound 8b) is an orally active CB2R agonist (EC50: 51.2 nM) and a weak TRPM8 antagonist. TRPM8 antagonist 4 prodrug is a prodrug of TRPM8 antagonist 4 (HY-174825) . TRPM8 antagonist 4 prodrug exhibits anti-inflammatory and analgesic activities and can be used in the research of inflammation-related pain disorders[1].
Product Specifications
UNSPSC
12352005
Target
Cannabinoid Receptor; Drug Intermediate; TRP Channel
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C/C(C)=C/CC/C(C)=C/COC1=CC(C2CC2)=C(C(N)=O)C(OC(C)=O)=C1
Molecular Formula
C22H29NO4
Molecular Weight
371.47
References & Citations
[1]Yang W, et al. Identification of Cannabigerol-Derived Dual CB2 Receptor Agonists and TRPM8 Antagonists with Anti-Inflammatory and Analgesic Activities. J Med Chem. 2025 Jul 10;68 (13) :13335-13357.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB2; TRPM8
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