P97-IN-1

P97-IN-1 is an orally active p97 inhibitor (IC50 = 26 nM) . p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML) [1].

Product Specifications

CAS Number

[3007658-96-7]

UNSPSC

12352005

Target

P97

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

CONC(C1=CC=CC2=C1C=C(N2C3=NC4=C(C(NCC5=CC=CC=C5)=N3)CCCN4)C)=O

Molecular Formula

C25H26N6O2

Molecular Weight

442.51

References & Citations

[1]Wang X, et al. Design and Synthesis of Novel 5,6,7,8-Tetrahydropyrido[2,3-D]pyrimidine Derivatives as VCP/p97 Inhibitors for the Treatment of Acute Myeloid Leukemia (AML) . Drug Des Devel Ther. 2025 May 27;19:4457-4479.