IRAK4-IN-32
IRAK4-IN-32 (Compound 10) is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an enzymatic IC50 value of 18.86 nM and a cellular IC50 value of 6.19 nM. IRAK4-IN-32 is promising for research of inflammatory and autoimmune diseases[1].
Product Specifications
UNSPSC
12352005
Target
IRAK
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CS(=O)(C1=CC=CC=C1NC2=NC(NC3=CC=C(N=C3)CO)=NC=C2Cl)=NC#N
Molecular Formula
C18H16ClN7O2S
Molecular Weight
429.88
References & Citations
[1]Kim K, et al. Synergistic optimizations of efficacy and membrane permeability of IRAK4 inhibitors: identifying new lead compounds for anti-inflammatory therapeutics. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2518491.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Curated Selection
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