HTS05585
HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM measured by microscale thermophoresis (MST) and 0.32±0.01 μM verified by isothermal titration calorimetry (ITC) . HTS05585 inhibits the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis[1].
Product Specifications
CAS Number
696643-14-8
UNSPSC
12352005
Target
Macrophage migration inhibitory factor (MIF)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
CCC1=CC2=NC(C3=CC(C4=CC=CC=C4)=NO3)=CN2C=C1
Molecular Formula
C18H15N3O
Molecular Weight
289.33
References & Citations
[1]Zhu S, et al. Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modelling, molecular docking, molecular dynamics simulations, and biological evaluation. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2501378.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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