EGFR/HER2-IN-19

EGFR/HER2-IN-19 (Compound L1) is a dual inhibitor against epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) . EGFR/HER2-IN-19 is promising for research of cancers driven by EGFR/HER2[1].

Product Specifications

CAS Number

[2229835-58-7]

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

COC(C=C1N=CN=C(C1=C2)NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=C2OCCCN5CCNCCNCCNCC5

Molecular Formula

C33H41ClFN7O3

Molecular Weight

638.18

References & Citations

[1]El Mehdi K, et al. Discovery of Novel Dual EGFR/HER2 Inhibitors Using Integrated Docking, Molecular Dynamics, and MMGBSA Computational Approaches[J]. ChemistrySelect, 2025, 10 (21) : e01410.