Topoisomerase IIα-IN-11
Topoisomerase IIα-IN-11 (Compound 16h) is a potent Topoisomerase IIα inhibitor. Topoisomerase IIα-IN-11 shows significant inhibition on melanoma A2058 cell lines (IC50 3-6 μM) . Topoisomerase IIα-IN-11 is promising for research of cancers (especially melanoma) [1].
Product Specifications
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(NC1=CC2=C(C3=CC=CC=C3N=C2C=C1)NCCCCC4=CC=CC=C4)CCN5CCCC5
Molecular Formula
C30H34N4O
Molecular Weight
466.62
References & Citations
[1]Janovec L, et al. Development of 2,9-Disubstituted Acridines as Topoisomerase IIα Inhibitors with Strong Anticancer Activity: Synthesis, Biological Evaluation, and In Silico Study. ChemMedChem. 2025 May 25:e2500267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Curated Selection
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