MAO-B-IN-44
MAO-B-IN-44 (Compound 4n) is a selective monoamine oxidase B (MAO-B) inhibitor targetin with an IC50 value of 1.01 μM, showing weak inhibition on MAO-A (IC50=14.4 μM) . MAO-B-IN-44 reduces degradation of neurotransmitters like dopamine. MAO-B-IN-44 is promising for research of neurodegenerative diseases related to MAO-B abnormalities such as Parkinson’s disease[1].
Product Specifications
CAS Number
[1454707-25-5]
UNSPSC
12352005
Target
Monoamine Oxidase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=C(NC2=CC=C(OC)C=C2)CC(C3=CC=C([N+]([O-])=O)C=C3)N(C4=CC=C(OC)C=C4)C1C5=CC=C([N+]([O-])=O)C=C5)OCC
Molecular Formula
C34H32N4O8
Molecular Weight
624.64
References & Citations
[1]Khan O R, et al. Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors[J]. ChemistryOpen, e202400516.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-A; MAO-B
Curated Selection
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