DPP-4-IN-16

DPP-4-IN-16 (Compound 92) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50=0.8 nM) . DPP-4-IN-16 inhibits DPP-4-mediated degradation of incretins (e.g., GLP-1 and GIP) to promote insulin secretion and reduce blood glucose. DPP-4-IN-16 is promising for research of type 2 diabetes[1].

Product Specifications

UNSPSC

12352005

Target

Dipeptidyl Peptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

[H]C1=C(N(C(N(C1=O)CC#CC)=O)N2CCC[C@@H](N)C2)CC3=C(Br)C=CC(C(O)=O)=C3

Molecular Formula

C21H23BrN4O4

Molecular Weight

475.34

References & Citations

[1]Kohal R, et al. Pyrimidine‐2, 4‐dione‐Based DPP‐4 Inhibitors: A Structure‐Guided Multifaced 3D‐QSAR and Molecular Dynamics Studies[J]. ChemistrySelect, 2025, 10 (22) : e00268.