ATR/PARP1-IN-1
ATR/PARP1-IN-1 is a potent ATR and PARP1 dual inhibitor with IC50s of 17.3 nM and 0.38 nM, respectively. ATR/PARP1-IN-1 effectively reduces cell viability, induces apoptosis and DNA damage. ATR/PARP1-IN-1 significantly impairs triple-negative breast cancer (TNBC) colony formation, migration, and invasion. ATR/PARP1-IN-1 suppresses tumor growth effectively in MDA-MB-468 xenografted mice, with no significant body weight change[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; ATM/ATR; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NCC1=NC(C2=C3C(NC=C3)=NC=C2)=NC(N4[C@H](C)COCC4)=C1)C5=CC=C(C(N6CCN(C(C7=CC(CC8=NNC(C9=C8C=CC=C9)=O)=CC=C7F)=O)CC6)=O)C=C5
Molecular Formula
C45H41FN10O5
Molecular Weight
820.87
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM; ATR; PARP1; PARP2; PARP7; PI3Kα; TNKS1/PARP5A; TNKS2/PARP5B
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