POLRMT-IN-2

POLRMT-IN-2 is a potent POLRMT inhibitor. POLRMT-IN-2 exhibits strong antiproliferative activity in MOLM-13 cells, with an IC50 of 1.01 μM. POLRMT-IN-2 disrupts mitochondrial function and induces apoptosis in MOLM-13cells. POLRMT-IN-2 can be used for the study of acute myeloid leukemia (AML) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

CC1=CC=C(C(C)=C1)C2=CC(OC3=C2C=CC(O[C@@H](C(N4C5CN(C(NC6=CC=CC(C#N)=C6)=O)CC4CC5)=O)C)=C3)=O

Molecular Formula

C34H32N4O5

Molecular Weight

576.64

References & Citations

[1]Liu T, Cheng X, Wang Y, Hao W, Wang H, Zhang K, Wang J. Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia. Chem Biol Drug Des. 2025 May;105 (5) :e70127.