EGFR-IN-164
EGFR-IN-164 (Compound 4) is a selective and covalent allosteric EGFR inhibitor. EGFR-IN-164 significantly inhibits the activity of EGFRL858R/T790M/C797S kinase (IC50: 48.1 nM) and proliferation of of EGFR-mutant cells. EGFR-IN-164 can be used for drug resistance of cancer research[1].
Product Specifications
UNSPSC
12352100
Target
C-Kit; EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CS(=O)(C=C)=NC1=CC=CC2=C1CN(C2)C(C3=CC(F)=CC=C3O)C(NC4=NC=CS4)=O
Molecular Formula
C23H21FN4O3S2
Molecular Weight
484.57
References & Citations
[1]Xu H, et al. Diethenyl Sulfoximine (DESI) as an Irreversible Lysine-Targeting Warhead Enables the Design of Covalent Allosteric EGFR Inhibitor. Chemistry. 2025 Jun 24:e202501389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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