EGFR-IN-164

EGFR-IN-164 (Compound 4) is a selective and covalent allosteric EGFR inhibitor. EGFR-IN-164 significantly inhibits the activity of EGFRL858R/T790M/C797S kinase (IC50: 48.1 nM) and proliferation of of EGFR-mutant cells. EGFR-IN-164 can be used for drug resistance of cancer research[1].

Product Specifications

UNSPSC

12352100

Target

C-Kit; EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C=CS(=O)(C=C)=NC1=CC=CC2=C1CN(C2)C(C3=CC(F)=CC=C3O)C(NC4=NC=CS4)=O

Molecular Formula

C23H21FN4O3S2

Molecular Weight

484.57

References & Citations

[1]Xu H, et al. Diethenyl Sulfoximine (DESI) as an Irreversible Lysine-Targeting Warhead Enables the Design of Covalent Allosteric EGFR Inhibitor. Chemistry. 2025 Jun 24:e202501389.