AZ'320
AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation[1].
Product Specifications
UNSPSC
12352005
Target
Necroptosis; RIP kinase
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O
Molecular Formula
C20H20N2O4S2
Molecular Weight
416.51
References & Citations
[1]Soday L, et al. Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1. ACS Chem Biol. 2025 Jun 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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