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VNRX-9945

VNRX-9945 is a potent, broadly and orally active HBV CAM (capsid assembly modulator) with an EC50 of 2.6 nM. VNRX-9945 exhibits excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. VNRX-9945 demonstrates robust antiviral efficacy in the adeno-associated virus mice models of HBV (AAV-HBV) infection[1].

Product Specifications

CAS Number

2396680-45-6

UNSPSC

12352005

Target

HBV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.4600

Smiles

O=C(C1=C(C)N(C)C(C(C(N[C@H]2CC[C@@H](O)CC2)=O)=O)=C1C)NC3=CC=C(F)C(C)=C3

Molecular Formula

C23H28FN3O4

Molecular Weight

429.48

References & Citations

[1]Bin Liu, et al. Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection. ACS Med. Chem. Lett. 2025, 16, 7, 1209–1216.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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