NOX5-IN-1

NOX5-IN-1 (Compound 13) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.30 μM. NOX5-IN-1 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 0.86 μM) . NOX5-IN-1 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation[1].

Product Specifications

UNSPSC

12352005

Target

NADPH Oxidase; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

CC(C1=CC=C2N=C(OC2=C1)SC3=C4C(N(N=N4)CC5=CC=CC=C5)=NC=N3)C

Molecular Formula

C21H18N6OS

Molecular Weight

402.47

References & Citations

[1]Ogboo BC, et al. Enhancing Selectivity and Potency of SNAr Covalent Inhibitors of NADPH Oxidase Enzymes. J Med Chem. 2025 Jul 10;68 (13) :14072-14084.