NOX5-IN-1
NOX5-IN-1 (Compound 13) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.30 μM. NOX5-IN-1 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 0.86 μM) . NOX5-IN-1 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation[1].
Product Specifications
UNSPSC
12352005
Target
NADPH Oxidase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
CC(C1=CC=C2N=C(OC2=C1)SC3=C4C(N(N=N4)CC5=CC=CC=C5)=NC=N3)C
Molecular Formula
C21H18N6OS
Molecular Weight
402.47
References & Citations
[1]Ogboo BC, et al. Enhancing Selectivity and Potency of SNAr Covalent Inhibitors of NADPH Oxidase Enzymes. J Med Chem. 2025 Jul 10;68 (13) :14072-14084.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DUOX1; NOX1; NOX2; NOX4; NOX5
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