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DHODH-IN-28

DHODH-IN-28 (Compound 11a) is a potent fluorescent inhibitor targeting human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 170 nM. DHODH-IN-28 exhibits antileukemic and antiviral activities. DHODH-IN-28 is promising for research of cancers and infectious diseases[1].

Product Specifications

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; Fluorescent Dye

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection

Smiles

OC1=NN2C=CC=CC2=C1/C=C/C3=C(F)C(F)=C(C4=CC=CC=C4)C(F)=C3F

Molecular Formula

C21H12F4N2O

Molecular Weight

384.33

References & Citations

[1]Sainas S, et al. Fluorescent Isostere (Fluostere) of the Carboxylate: Design of hDHODH Fluorescent Inhibitors as Proof of Concept. J Med Chem. 2025 Jul 10;68 (13) :13562-13590.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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