DHODH-IN-28
DHODH-IN-28 (Compound 11a) is a potent fluorescent inhibitor targeting human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 170 nM. DHODH-IN-28 exhibits antileukemic and antiviral activities. DHODH-IN-28 is promising for research of cancers and infectious diseases[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Fluorescent Dye
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Infection
Smiles
OC1=NN2C=CC=CC2=C1/C=C/C3=C(F)C(F)=C(C4=CC=CC=C4)C(F)=C3F
Molecular Formula
C21H12F4N2O
Molecular Weight
384.33
References & Citations
[1]Sainas S, et al. Fluorescent Isostere (Fluostere) of the Carboxylate: Design of hDHODH Fluorescent Inhibitors as Proof of Concept. J Med Chem. 2025 Jul 10;68 (13) :13562-13590.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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