Pomalidomide-PEG3-Cys

Pomalidomide-PEG3-Cys is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand Pomalidomide (HY-10984) and 3-unit PEG linker. Pomalidomide-PEG3-Cys can be used for synthesis of PROTAC BRD4 Degrader-33 (HY-174811) [1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Others

Smiles

O=C(CCC1N(C2=O)C(C3=C2C(NC(COCCOCCOCCNC([C@H](N)CS)=O)=O)=CC=C3)=O)NC1=O

Molecular Formula

C24H31N5O9S

Molecular Weight

565.60

References & Citations

[1]Sun C, et al. Enzyme-Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment-Responsive Immunomodulation. Angew Chem Int Ed Engl. 2025 May 26;64 (22) :e202423057.