BRD4 ligand 8
BRD4 ligand 8 (Compound J558) is a BRD4 inhibitor. BRD4 ligand 8 can be used for synthesis of PROTAC BRD4 Degrader-33 (HY-174811) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Related Pathways
Epigenetics; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C[C@@H]1C2=NN=C(N2C(S3)=C(C(C)=C3C)C(C(C=C4)=CC=C4Cl)=N1)C)NC5=CC=C6N=C(C#N)SC6=C5
Molecular Formula
C27H20ClN7OS2
Molecular Weight
558.08
References & Citations
[1]Sun C, et al. Enzyme-Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment-Responsive Immunomodulation. Angew Chem Int Ed Engl. 2025 May 26;64 (22) :e202423057.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Curated Selection
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