PROTAC BRD4 Degrader-33
PROTAC BRD4 Degrader-33 is an enzyme activated clickable BRD4 PROTAC degrader with favorable tumor microenvironment-response. PROTAC BRD4 Degrader-33 has superior tumor tissue penetration capabilities and efficiently inhibits PD-L1 protein expression. PROTAC BRD4 Degrader-33 shows potent anti-tumoral immunomodulation activity in 4T1 tumor-bearing mice model[1]. Pink: BRD4 ligand ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PD-1/PD-L1; PROTACs
Related Pathways
Epigenetics; Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(CCC1N(C2=O)C(C3=C2C(NC(COCCOCCOCCNC(C4N=C(C5=NC6=CC=C(NC(C[C@@H]7C8=NN=C(N8C(S9)=C(C(C)=C9C)C(C(C=C%10)=CC=C%10Cl)=N7)C)=O)C=C6S5)SC4)=O)=O)=CC=C3)=O)NC1=O
Molecular Formula
C51H48ClN11O10S3
Molecular Weight
1106.64
References & Citations
[1]Sun C, et al. Enzyme-Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment-Responsive Immunomodulation. Angew Chem Int Ed Engl. 2025 May 26;64 (22) :e202423057.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
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