PROTAC BRD4 Degrader-33

PROTAC BRD4 Degrader-33 is an enzyme activated clickable BRD4 PROTAC degrader with favorable tumor microenvironment-response. PROTAC BRD4 Degrader-33 has superior tumor tissue penetration capabilities and efficiently inhibits PD-L1 protein expression. PROTAC BRD4 Degrader-33 shows potent anti-tumoral immunomodulation activity in 4T1 tumor-bearing mice model[1]. Pink: BRD4 ligand (HY-174812) ; Blue: CRBN ligase ligand (HY-10984) ; Black: linker

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PD-1/PD-L1; PROTACs

Related Pathways

Epigenetics; Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(CCC1N(C2=O)C(C3=C2C(NC(COCCOCCOCCNC(C4N=C(C5=NC6=CC=C(NC(C[C@@H]7C8=NN=C(N8C(S9)=C(C(C)=C9C)C(C(C=C%10)=CC=C%10Cl)=N7)C)=O)C=C6S5)SC4)=O)=O)=CC=C3)=O)NC1=O

Molecular Formula

C51H48ClN11O10S3

Molecular Weight

1106.64

References & Citations

[1]Sun C, et al. Enzyme-Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment-Responsive Immunomodulation. Angew Chem Int Ed Engl. 2025 May 26;64 (22) :e202423057.