NPB-1575

NPB-1575 is a potent, orally active and brain-penetrant anti-inflammatory agent. NPB-1575 mitigates neuroinflammation and resists ferroptosis by activating the IRS2/Nrf2/NF-κB axis. NPB-1575 shows protective effect against cerebral ischemic injury and improves the neurological functional prognosis. NPB-1575 can be used for the study of ischemic stroke[1].

Product Specifications

CAS Number

[161984-54-9]

UNSPSC

12352005

Target

Ferroptosis; FOXO; Keap1-Nrf2; NF-κB; NO Synthase; Quinone Reductase

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

OC1=CC(O)=C(C/C=C(C)/C)C(CCC2=CC(O)=C(O)C=C2)=C1

Molecular Formula

C19H22O4

Molecular Weight

314.38

References & Citations

[1]Li XN, et al. NPB-1575 attenuates neuroinflammation and resists ferroptosis in rat ischemic stroke via IRS2 signaling pathway. Acta Pharmacol Sin. 2025 Jun 5.