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Y040-7904

Y040-7904 is a mitophagy activator. Y040-7904 enhances mitophagy by promoting mitochondria transport to autophagosomes and the fusion of autophagosomes with autolysosomes. Y040-7904 induces mitophagy through the SIRT1/FoxO3 pathway. Y040-7904 upregulates the levels of Parkin, PINK1, and LC3II/I. Y040-7904 reduces amyloid-β (Aβ) accumulation in both in vitro and in vivo models of Alzheimer’s disease[1].

Product Specifications

CAS Number

[889662-19-5]

Product Name Alternative

7- (β-D-Galactopyranosyloxy) -4-phenylchromen-2-one

UNSPSC

12352005

Target

Amyloid-β; Mitophagy; PINK1/Parkin

Related Pathways

Autophagy; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.3600

Smiles

O=C1C=C(C2=CC=CC=C2)C3=CC=C(O[C@H]4[C@@H]([C@H]([C@@H](CO4)O)O)O)C=C3O1

Molecular Formula

C20H18O7

Molecular Weight

370.35

References & Citations

[1]Wang Y, et al. An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates. Nat Commun. 2025 Jun 4;16 (1) :5179.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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