WMJ-J-09
WMJ-J-09 is an HDAC inhibitor with IC50 values of 7.5 nM (HDAC1), 21.3 nM (HDAC2), 18.4 nM (HDAC3), 90.9 nM (HDAC8), 3.9 nM (HDAC6) and 8715.7 nM (HDAC4) . WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research[1][2].
Product Specifications
CAS Number
2416914-29-7
UNSPSC
12352100
Target
AMPK; Apoptosis; HDAC; MDM-2/p53; Microtubule/Tubulin; p38 MAPK; Pim; Survivin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Purity
98.44
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NO)CCCCCCC(NC1=CC(N(S(C2=CC=CC=C2)(=O)=O)CC3)=C3C=C1)=O
Molecular Formula
C22H27N3O5S
Molecular Weight
445.53
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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