XL-3156
XL-3156 is a potent, selective, and cross-species cGAS inhibitor. XL-3156 can simultaneously occupy both allosteric and orthosteric sites, and inhibit the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of autoimmune diseases, inflammatory conditions and other diseases[1].
Product Specifications
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=NN(C(O)=C1C(C2=C(N(N=C2C)C3=NC4=CC=CC=C4N3)O)C5=NC=CC=C5)C6=NC7=CC=CC=C7N6
Molecular Formula
C28H23N9O2
Molecular Weight
517.54
References & Citations
[1]Zhao W, et al. De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS. Nat Commun. 2025 Jun 3;16 (1) :5140.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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